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MUSCULOSKELETAL AND CONNECTIVE TISSUE DISEASES
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Systemic Lupus Erythematosus Juvenile Arthritis Scleroderma Ankylosing Spondylitis
Sjogren's Syndrome Polymyalgia Rheumatica Polymyositis Osteomyelitis
Mixed Connective Tissue Disease Paget's Disease Infectious Arthritis Osteogenic Sarcoma
Reiter's Syndrome Metastatic Carcinoma of Bone Rheumatoid Arthritis .
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ANKYLOSING SPONDYLITIS
- Disussion: - patients with ankylosing spondylitis are prone to C-spine fracture following minor trauma; - acute neck pain in a patient with ankylosing spondylitis is usually caused by a fracture through the ankylosed spine; - site of involvement is most commonly near cervicothoracic junction (or C6-7); - the fracture may extend thru the disc space or may extend thru all columns; - there may be significant change in neck alignment; - epidural hematoma may contribute to spinal cord injury;

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LABORATORY FINDINGS

  • Increased sedimentation rate and C-reactive protein (90%)
  • Normocytic, hypochromic anaemia (<30%) - chronic disease type
  • Presence of HLBA-B27 antigen in 90% of patients
  • Increased alkaline phosphatase (50%) - reflects inflammation, immobilization and resorption of bones
  • Synovial-fluid findings are similar to those in rheumatoid arthritis
  • Negative rheumatoid factor
Laboratory Findings of Associated diseases
  • Ulcerative colitis*
  • Regional ileitis*
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