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Serology Results Interpretation
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Interpreting Hepatitis B Serology
Tests Results Interpretation
HBsAg
anti-HBc
anti-HBs
negative
negative
negative

susceptible
HBsAg
anti-HBc
anti-HBs
negative
positive
positive
immune due to natural infection
HBsAg
anti-HBc
anti-HBs
negative
negative
positive
immune due to Hepatitis B vacination
HBsAg
anti-HBc
IgM anti-HBcanti-HBs
positive
positive
positive
negative
acutely infected
HBsAg
anti-HBc
IgM anti-HBc
anti-HBs
positive
positive
negative
negative
chronically infected
HBsAg
anti-HBc
anti-HBs
negative
positive
negative

four interpretations possible*
* 1. May be recovering from Acute HBV infection
2. May be distantly immune and test not sensitive enough to detect very low level of anti-HBs in serum
3. May be susceptible with a false positive anti-HBc
4. May be undetectable level of HBsAg present in the serum and the person is actually a carrier.

Source: National Center for Infectious Diseases

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