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MUSCULOSKELETAL AND CONNECTIVE TISSUE DISEASES
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Systemic Lupus Erythematosus Juvenile Arthritis Scleroderma Ankylosing Spondylitis
Sjogren's Syndrome Polymyalgia Rheumatica Polymyositis Osteomyelitis
Mixed Connective Tissue Disease Paget's Disease Infectious Arthritis Osteogenic Sarcoma
Reiter's Syndrome Metastatic Carcinoma of Bone Rheumatoid Arthritis .
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SCLERODERMA

Click on images for link to source documents (Indiana Uni)

LABORATORY FINDINGS
  • *Presence of antinuclear antibodies (60%) - nucleolar and speckled patterns are characteristic
  • Increased sedimentation rate (30%) reflects disease activity.
  • Normochromic, normocytic anaemia (25% - 30%) - chronic disease type
  • Increased serum y-globulin, especially IgG - indicates immunoglobulin stimulation
  • Presence of small amounts of cryoglobulins (50% of patients)
  • Absence of antibodies to native DNA and Sm antigen.
  • Biopsy of skin - usually of help only late in the disease
Laboratory Findings that Reflect Specific Organ Involvement
  • Kidney - scleroderma renal disease
  • Small intestine - malabsorption
  • Heart - pericarditis
  • Lung - dminished gas diffusion due to interstitial fibrosis;  pneumonia
  • Muscle - polymyositis

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